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STK393606
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
STK393606图片
CAS NO:355827-05-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt345.2
Cas No.355827-05-3
FormulaC14H9BrN4S
Solubility≤12mg/ml in DMSO;14mg/ml in dimethyl formamide
Chemical Name2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-benzonitrile
Canonical SMILESBrC1=CNC2=NC(SCC3=CC=CC=C3C#N)=NC2=C1
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Target: NAD+-dependent type-I 15-hydroxy PGDH

IC50: 26.4 nM

Ki: 5 nM

STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH, with the IC50 value of 26.4±2.4 nM, and the Ki value of 5 nM, which could cause a maximum of 100% inhibition [1].

Hydroxyprostaglandin dehydrogenase 15-(NAD), also called 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH), is a critical enzyme participated in the inactivation of prostaglandins (PGs) and related eiscosanoids. 15-hydroxy PGDH belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of substrates with NAD+ or NADP+ as acceptor. 15-hydroxy PGDH could catalyze the oxidation of primary PGs to their 15-keto metabolites [2]. Radioimmunoassay for 15-hydroxy prostaglandin dehydrogenase had identified two types of enzyme activity, of which type-I used NAD+ as a cofactor, while type-II used NADP+ as a cofactor and bear wider substrate specificity [3].

In Vitro: no data available.

In Vivo: no data available.

Clinical trial: no data available.

References:
[1] Niesen F H, Schultz L, Jadhav A, et al.  High-Affinity Inhibitors of Human NAD + -Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships[J]. PLOS ONE, 2010, 5(11).
[2] Tai H, Ensor C M, Tong M, et al.  Prostaglandin catabolizing enzymes.[J]. Prostaglandins & Other Lipid Mediators, 2002: 483-493.
[3] Lee S C, Levine L.  Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.[J]. Journal of Biological Chemistry, 1975, 250(2): 548-552.