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L-NIO(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-NIO(hydrochloride)图片
CAS NO:36889-13-1
包装与价格：
包装价格(元)
50mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt246.1
Cas No.36889-13-1
FormulaC7H15N3O2·2HCl
Solubility≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical NameN5-(1-iminoethyl)-L-ornithine, dihydrochloride
Canonical SMILESCC(=N)NCCC[C@H](N)C(=O)O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

IC50: 1.7, 3.9, and 3.9 μM for nNOS (rat), eNOS (bovine), and iNOS (mouse), respectively

L-NIO is a NOS inhibitor.

Nitric oxide synthases (NOSs) are enzymes that catalyze the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule and helps modulate vascular tone, airway tone, insulin secretion, and peristalsis. NO is involved in angiogenesis and neural development.

In vitro: Three analogues of L-arginine were characterized as inhibitors of endothelial NO synthase by measuring their effect on the endothelial NO synthase from porcine aortae. It was found that L-NMMA, L-NIO and L-NAME could cause concentration-dependent inhibition of the Ca2+-dependent endothelial NO synthase [1].

In vivo: In rats, L-NMMA, L-NIO and L-NAME could induce a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Moreover, L-NMMA, L-NIO and L-NAME at i.v. 100 mg/kg significantly inhibited the hypotensive responses to ACh and bradykinin. The increase in blood pressure and bradycardia produced by these compounds were able to be reversed by L-arginine in a dose-dependent manner. Moreover, all of these effects were enantiomer specific [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] D.  D. Rees, R. M. J. Palmer, R. Schulz, et al. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. British Journal of Pharmacology 101, 746-752 (1990).