| CAS NO: | 111149-87-2 |
| 包装: | 1mg |
| 市场价: | 2212元 |
| Physical Appearance | An oil |
| Storage | Store at -20°C |
| M.Wt | 386.6 |
| Cas No. | 111149-87-2 |
| Formula | C25H38O3 |
| Solubility | Soluble in ethanol;Soluble in DMSO |
| Chemical Name | 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-2(5H)-furanone |
| Canonical SMILES | CC1(C)CCCC(C)=C1CC/C(C)=C/CC/C(C)=C/CCC2=CC(OC2O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Luffariellolide is an agonist for the RA receptors RAR α, β, and γ.
Retinoids show anti-tumour activity on various cancer cells and thus have been used as important therapeutic agents. However, adverse side effects and retinoic acid (RA) resistance limit its further development.
In vitro: Previous study reported the identification of luffariellolide, a natural marine product activating RA receptors (RARs) with a chemical structure distinct from retinoids by high-throughput screening. Luffariellolide was found to be a novel RAR agonist via inducing co-activator binding to RA receptors, further inhibiting cell growth and regulating RAR target genes in various cancer cells [1].
In vivo: In a previous animal study, paw edema was produced in CD-1 mice by the injection snake venom PLA2 into the hind paw. It was found that luffariellolide and aristolochic acid could reduce the edema but only when coinjected with the PLA2. Similarly, the PAF antagonists, CV-6202 and kadsurenone (coinjected) were also able to reduce the PLA2-induced edema, and high doses of the corticosteroids, dexamethasone and hydrocortisone were also effective [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Wang S, Wang Z, Lin S, Zheng W, Wang R, Jin S, Chen J, Jin L, Li Y. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J. 2012 Aug 15;446(1):79-87.
[2] Calhoun, W. ,Yu, J.,Sung, A., et al. Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. Agents and Actions 27, 418-421 (1989).
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