Flavin adenine dinucleotide

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CAS NO:

146-14-5

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	785.55
Cas No.	146-14-5
Formula	C₂₇H₃₃P₂N₉O₁₅
Solubility	insoluble in EtOH; insoluble in DMSO; ≥196.5 mg/mL in H2O
Chemical Name	A name could not be generated for this structure.
Canonical SMILES	CC1=CC(N=C(C(O)=N2)C3=NC2=O)=C(N3C[C@@](O)([H])[C@@](O)([H])[C@@](O)([H])COP(O)(OP(O)(OC[C@](O4)([H])[C@](O)([H])[C@](O)([H])[C@]4([H])N5C=NC(C5=NC=N6)=C6N)=O)=O)C=C1C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Flavin adenine dinucleotide is used as a redox cofactor by a variety of proteins involved in several important enzymatic reactions in metabolism. In human, most flavoproteins contain one or more loosely bound flavin adenine dinucleotide moieties. Flavoproteins include the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, folate/FAD-dependent tRNA methyltransferases, N-hydroxylating flavoprotein monooxygenases, and apoptosis-inducing factor 2. Flavoproteins are predominately located in the mitochondria due to their redox power. Of all flavoproteins, more than 90% perform redox reactions and ~ 10% are lyases, transferases, isomerases and ligases involved in nonredox reactions.

References:

1. Kohlmeier M. Chapter 10 - Water-Soluble Vitamins and Nonnutrients. Nutrient Metabolism (Second Edition), 2015, 567-671.

2. Lienhart WD, Gudipati V, Macheroux P. The human flavoproteome. Archives of Biochemistry and Biophysics, 2013, 535(2): 150-162.

3. Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS Journal, 2011, 278(15): 2625-2634.

4. Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Japanese Heart Journal, 1979, 20(5): 657-665.

试验操作

Animal experiment:[4]
Animal models	Dogs
Dosage form	2 mg/kg Intravenous injection
Applications	Flavin adenine dinucleotide significantly canceled the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Also, flavin adenine dinucleotide counteracted the effects of CPZ on canine heart mitochondria. Thus, flavin adenine dinucleotide might be useful in the treatment of the cardiac disturbances associated with overdosage of CPZ.
Note	The technical data provided above is for reference only.
	References: 1. Kohlmeier M. Chapter 10 - Water-Soluble Vitamins and Nonnutrients. Nutrient Metabolism (Second Edition), 2015, 567-671. 2. Lienhart WD, Gudipati V, Macheroux P. The human flavoproteome. Archives of Biochemistry and Biophysics, 2013, 535(2): 150-162. 3. Macheroux P, Kappes B, Ealick SE. Flavogenomics--a genomic and structural view of flavin-dependent proteins. The FEBS Journal, 2011, 278(15): 2625-2634. 4. Sugiyama S, Ozawa T. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Japanese Heart Journal, 1979, 20(5): 657-665.