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Ciprofloxacin(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ciprofloxacin(hydrochloride)图片
CAS NO:93107-08-5
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议
50g电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt367.8
Cas No.93107-08-5
FormulaC17H18FN3O3·HCl
SynonymsBAY-o 9867,NSC 620634
Solubilityinsoluble in EtOH; ≥33.87 mg/mL in H2O; ≥9.34 mg/mL in DMSO with ultrasonic
Chemical Name1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, monohydrochloride
Canonical SMILESFC1=CC2=C(C=C1N3CCNCC3)N(C4CC4)C=C(C(O)=O)C2=O.Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin functions by inhibiting DNA gyrase and topoisomerase IV, the enzymes responsible for negative supercoiling of chromosomes and DNA strand separation, thus blocking initiation of bacterial replication. Topoisomerase IV is the primary target of ciprofloxacin in S. aureus [2].

Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that acts as an antimicrobial and immunomodulatory agent. In B6D2F1/J mice received radiation combined injury (CI), Ciprofloxacin significantly reduced pro-inflammatory cytokine and chemokine concentrations (IL-6 and KC), and enhanced IL-3 production. CIP also inhibited CI-induced apoptosis and autophagy in ileal villi, systemic bacterial infection, and IgA production [1]. Ciprofloxacin (hydrochloride) had been approved by FDA for management of postexposure inhalational anthrax. In animals after exposure to aerosolized B. anthracis, ciprofloxacin significantly improved survival rate. Ciprofloxacin inhibited the growth of B. anthracis with MIC90 of 0.06 μg/mL. In the USAMRIID rhesus monkey model of inhalational anthrax, the maximum concentration (Cmax) of Ciprofloxacin was 1.74 μg/mL and the minimum concentration (Cmin) was 0.17 μg/mL [3].

References:
[1].  Fukumoto R, Cary LH, Gorbunov NV, et al. Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma. PLoS One. 2013;8(3):e58389.
[2].  Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.
[3].  Meyerhoff A, Albrecht R, Meyer JM, et al. US Food and Drug Administration approval of ciprofloxacin hydrochloride for management of postexposure inhalational anthrax. Clin Infect Dis. 2004 Aug 1;39(3):303-8.