您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > U-44069
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
U-44069
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
U-44069图片
CAS NO:56985-32-1
包装与价格:
包装价格(元)
1mg (solution)电议
5mg (solution)电议
10mg (solution)电议

产品介绍

化学性质

Physical AppearanceA solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt350.5
Cas No.56985-32-1
FormulaC21H34O4
Synonyms9,11-dideoxy-9α,11α-epoxymethano PGF2α,9,11-dideoxy-9α,11α-epoxymethano Prostaglandin F2α,9,11-epoxymethano Prostaglandin H2
Solubility≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide
Chemical Name9,11-dideoxy-9α,11α-epoxymethano-prosta-5Z,13E-dien-1-oic acid
Canonical SMILESCCCCC[C@H](O)/C=C/[C@H]1C(CO2)CC2[C@@H]1C/C=C\CCCC(O)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

EC50: 3 μM and 54 nM for platelet aggregation and phosphatidate formation in human platelets, respectively

U-44069 is a TP receptor agonist.

Increased production of vasoconstrictive prostanoids, such as thromboxane A2, contributes to endothelial dysfunction and increased hepatic vascular tone in cirrhosis. Thromboxane A2 induces vasoconstriction via activation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor.

In vitro: In a previous study, dose-response relationships for raised cytoplasmic free calcium concentration and shape change were simultaneously measured. With the calcium ionophore ionomycin the threshold of free calcium concentration for shape change was 300 nM with a maximal response at 800 nM. With 1 mM external free calcium concentration the U44069 concentrations required to stimulate half-maximal shape change and an increase in free calcium concentration were 2 and 41 nM, respectively. Low levels of U44069 could evoke substantial shape change without any rise in free calcium concentration. In the absence of external calcium, U44069 was able to stimulate half-maximal shape change at 2 nM, and half-maximal elevation of free calcium concentration at 69 nM [1].

In vivo: Animal study showed that naive mice treated with either U-44069 at 25 or 100 μg/kg (iv), endothelin-1 (100 pmol, intranasally) or the ET B receptor agonist IRL-1620 (100 pmol, intranasally) had a marked increase in airway reactivity to carbachol [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Simpson, A. W.M.,Hallam, T.J., and Rink, T.J. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. FEBS Letters 201, 301-305 (1986).
[2] Richter M, Cloutier S, Sirois P.  Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):299-308.