Avibactam sodium

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Avibactam sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1192491-61-4

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	287.23
Cas No.	1192491-61-4
Formula	C₇H₁₀N₃NaO₆S
Solubility	≥28.7 mg/mL in DMSO; insoluble in EtOH; ≥48.2 mg/mL in H2O
Chemical Name	sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
Canonical SMILES	O=S(ON1[C@@]2(CC[C@H]([N@](C1=O)C2)C(N)=O)[H])([O-])=O.[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Avibactam sodium is a β-lactamase inhibitor that does not include the β-lactam core but maintains the capacity to covalently acylate its β-lactamase targets. Avibactam sodium inhibits β-lactamases CTX-M-15 and TEM-1, with IC50 values of 5 and 8 nM, respectively. β-Lactamases are enzymes produced by bacteria, with the ability to inactivate β-lactam antibiotics by hydrolyzing the β-lactam ring. β-Lactamases are responsible for resistance to penicillins, monobactams, carbapenems, and extended-spectrum cephalosporins. Avibactam sodium combined with β-lactam antibiotics can be potentially used for the treatment of bacterial infections comprising Gram-negative organisms.

References:

1. Ehmann DE, Jahic H, Ross PL, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(29): 11663-11668.

2. Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clinical Microbiology Reviews, 2010, 23(1): 160-201.

3. Berkhout J, Melchers MJ, van Mil AC, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrobial Agents and Chemotherapy, 2015, 59(4): 2299-2304.

试验操作

Animal experiment:[3]
Animal models	A covalent, reversible, non-β-lactam β-lactamase inhibitor
Dosage form	1 ~ 128 mg/kg Subcutaneous administration
Applications	No pharmacokinetic interaction between ceftazidime and avibactam was observed. Ceftazidime and avibactam showed linear plasma pharmacokinetics that were independent of the dose combinations used or the infection site in mice.
Note	The technical data provided above is for reference only.
	References: 1. Ehmann DE, Jahic H, Ross PL, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(29): 11663-11668. 2. Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clinical Microbiology Reviews, 2010, 23(1): 160-201. 3. Berkhout J, Melchers MJ, van Mil AC, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrobial Agents and Chemotherapy, 2015, 59(4): 2299-2304.