| CAS NO: | 581-05-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1664.9 |
| Cas No. | 581-05-5 |
| Formula | C77H109N21O19S1 |
| Synonyms | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide |
| Solubility | insoluble in EtOH; ≥10.44 mg/mL in H2O with ultrasonic; ≥166.5 mg/mL in DMSO with gentle warming |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
α-MSH，酰胺（C77H109N21O19S1），序列为Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2，分子量为1664.9。促黑素细胞激素，统称为MS或intermedins，是一类由垂体中叶细胞产生的多肽激素。MSH的增加导致人变黑。怀孕期间促黑素增加，伴随着雌激素的增加，引起孕妇色素沉着增多。库欣综合征是由于过量促肾上腺皮质激素（ACTH）导致色素沉着过度，例如腋窝黑棘皮症。大多数患有原发性阿狄森氏症的患者皮肤变黑（色素沉着过度），包括不暴露在太阳的部位，特征是皮肤皱折（例如手中）、乳头及脸颊（颊粘膜）的内部，旧疤痕可能会变暗。这是因为促黑素（MSH）和促肾上腺皮质激素（ACTH）具有相同的前体分子阿黑皮素原（POMC）。
促黑素是黑皮质素的一员，包括促肾上腺皮质激素、α-促黑素细胞激素（α-MSH）、（β-MSH）和（γ-MSH），这几个多肽是由前体肽阿黑皮素原（POMC）裂解的产物。α-MSH是色素沉着中最重要的黑皮质素。
Figure1 Formula of a-MSH, amide
参考文献：
1. Hadley ME (Oct 2005). "Discovery that a melanocortin regulates sexual functions in male and female humans".Peptides26 (10): 1687–9.
2. MillingtonGW (May 2006). "Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors".Clin. Exp. Dermatol.31 (3): 407–12
3. MillingtonGW (2007). "The role of proopiomelanocortin (POMC) neurones in feeding behaviour".Nutr Metab (Lond)4: 18.
| Animal experiment:[1] | |
Animal models | IL-10-deficient mice |
Dosage form | 50 μg/0.2 ml saline Injected intraperitoneally |
Applications | α-MSH given systemically effectively alleviated acute inflammatory reactions induced by an irritant (picryl chloride 0.5% in acetone) applied to the ear. The relative inhibition (percent of percent change) with α-MSH was virtually the same in both IL-10–deficient and in control animals (approximately 70%). α-MSH modulated all forms of inflammation by acting on peripheral inflammatory cells, glial inflammatory cells, and on central nervous system receptors that activate descending anti-inflammatory neural pathways. |
Note | The technical data provided above is for reference only. |
References: 1. Lipton JM, Zhao H, Ichiyama T, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Annals of the New York Academy of Sciences, 1999, 885: 173-182. | |
m.cnreagent.com