您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > PF-05089771 Tosylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PF-05089771 Tosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-05089771 Tosylate图片
CAS NO:1430806-04-4
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 672.54
FormulaC25H20Cl2FN5O6S3
CAS No.1430806-04-4 (tosylate);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:>35 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESO=S(C1=CC(Cl)=C(OC2=CC=C(Cl)C=C2C3=CNN=C3N)C=C1F)(NC4=CSC=N4)=O.OS(=O)(C5=CC=C(C) C=C5)=O
SynonymsPF-05089771 Tosylate; PF 05089771 Tosylate; PF05089771 Tosylate
实验参考方法
In Vitro

In vitro activity: PF-05089771 is a potent and subtype selective NaV1.7 inhibitor with IC50 of 11 nM. It binds to a site in the voltage sensing domain and interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block that is depolarization and concentration dependent, with a similarly slow recovery from block. Furthermore, the onset of block by PF-05089771 develops with similar rates using protocols that bias channels into predominantly fast- or slow-inactivated states, suggesting that channel inhibition is less dependent on the availability of a particular inactivated state than the relative time that the channel is depolarized.


Kinase Assay: PF-05089771 is a potent and subtype selective NaV1.7 inhibitor with IC50 of 11 nM. It binds to a site in the voltage sensing domain and interacts with the voltage-sensor domain (VSD) of domain IV.


Cell Assay:

In Vivo
Animal model
Formulation & Dosage
References J Med Chem. 2017 Aug 24;60(16):7029-7042.