| CAS NO: | 128-37-0 |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| Storage | Store at -20°C |
| M.Wt | 220.35 |
| Cas No. | 128-37-0 |
| Formula | C15H24O |
| Solubility | ≥22 mg/mL in EtOH; insoluble in H2O; ≥81.6 mg/mL in DMSO |
| Chemical Name | 2,6-di-tert-butyl-4-methylphenol |
| Canonical SMILES | CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Butylated hydroxytoluene (BHT) is a synthetic phenolic product and a widely used antioxidant.
BHT inhibits the proliferation of mouse testicular interstitial Leydig cells (TM3) and arrests the cell cycle. It disrupts the cytoplasm and mitochondrial cartilage calcium homeostasis. BHT also causes endoplasmic reticulum (ER) stress and DNA breaks[1].
In female mice, BHT causes significant fibrotic areas and proliferative AEC in the lungs. And it changes the distal lung parenchymal signals involved in pulmonary fibrosis, which has certain similarities with human IPF in the pathway involving Col V[2].
[1]. Ham J, Lim W, Whang K Y, Song G. Butylated hydroxytoluene induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in mouse Leydig cell death. Environ Pollut, 2020, 256: 113421
[2]. Teodoro W R. Butylated hydroxytoluene induces type-v collagen and overexpression of remodeling genes/proteins in experimental lung fibrosis. Histology & Histopathology, 2018, 33, 1111-1123.
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