Tauroursodeoxycholic Acid

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

14605-22-2

包装与价格：

包装	价格(元)
500mg	电议
1g	电议
5g	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	499.7
Cas No.	14605-22-2
Formula	C₂₆H₄₅NO₆S
Solubility	≥50 mg/mL in DMSO; ≥4.8 mg/mL in H2O with ultrasonic; ≥55.7 mg/mL in EtOH
Chemical Name	2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid
Canonical SMILES	C[C@H](CCC(NCCS(O)(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Tauroursodeoxycholic acid (TUDCA) is a taurine conjugate product of ursodeoxycholic acid, which can be used as a mitochondrial stabilizer and anti-apoptotic agent.

In endoplasmic reticulum stress conditions, TUDCA treatment of MSCs (mesenchymal stem cells) reduces the activation of ER stress-associated proteins and inhibits the dissociation between GRP78 and PERK, thereby reducing endoplasmic reticulum stress Mediated cell death.

In a murine hindlimb ischemia model, TUDCA-treated mesenchymal stem cells (MSCs) transplantation can increase blood perfusion ratio, promote blood vessel formation, and improve the survival rate of transplanted cell more than untreated MSC transplantation does.

Reference:

[1]. Yoon Y M, Lee J H, Yun S P, et al. Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein. Scientific Reports, 2016, 6(1): 39838.