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Methyl 3,4-dihydroxybenzoate(Protocatechuic acid methyl ester)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Methyl 3,4-dihydroxybenzoate(Protocatechuic acid methyl ester)图片
CAS NO:2150-43-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
3,4-二羟基苯甲酸甲酯（原儿茶酸甲酯）（原儿茶酸甲酯；原儿茶酸甲酯）是绿茶中发现的抗氧化多酚的主要代谢物。
Cas No.2150-43-8
别名3,4-二羟基苯甲酸甲酯,Protocatechuic acid methyl ester; Methyl protocatechuate
Canonical SMILESO=C(OC)C1=CC=C(O)C(O)=C1
分子式C8H8O4
分子量168.15
溶解度DMSO : ≥ 100 mg/mL (594.71 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect[1].

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) alleviates the toxic effects of F- via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells[1].

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester;Methyl protocatechuate) (25 or 50 mg/kg bw/day) prevents the cellular F- accumulation and oxidative stress. It prevents the inflammatory and associated fibrosis progression by restoring the expression of RAGE and Nrf2[2].

[1]. Ameeramja J, et al. Protocatechuic acid methyl ester ameliorates fluoride toxicity in A549 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):941-950. [2]. Ameeramja J, et al. Protocatechuic acid methyl ester modulates fluoride induced pulmonary toxicity in rats. Food Chem Toxicol. 2018 Aug;118:235-244.