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Sodium Oxamate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium Oxamate图片
CAS NO:565-73-1
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议
50g电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt111.03
Cas No.565-73-1
FormulaC2H2NNaO3
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥11.1 mg/mL in H2O
Chemical Namesodium 2-amino-2-oxoacetate
Canonical SMILES[O-]C(C(N)=O)=O.[Na+]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Sodium oxamate is a competitive LDHA(actate dehydrogenase A) inhibitor, sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors[1,2].

References:

[1]. Anna Z K, De S M M L, Antonio S, et al. Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells. PLOS ONE, 2015, 10(3): e0119857.

[2]. Cui J, Shi M, Xie D, et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clinical Cancer Research, 2014, 20(10): 2595-2606.