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LDN-0088050
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LDN-0088050图片
CAS NO:353484-30-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LDN 0088050 是一种选择性的脂肪酸结合蛋白 (AFABP, FABP4) 抑制剂,FABP4、FABP3 的 Ki 值分别为 0.29、1.3 μM. LDN 0088050 结合 FABP4 的Kd 值为 2.05 μM。
Cas No.353484-30-7
Canonical SMILESOC(C(C1C2C=CC1)N3CC4C(C=CC4)C5=CC(Br)=CC2=C35)=O
分子式C19H18BrNO2
分子量372.26
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1]

LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1].

[1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317.