| CAS NO: | 69-52-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL H2O) | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| Storage | Store at -20°C |
| M.Wt | 371.4 |
| Cas No. | 69-52-3 |
| Formula | C16H18N3NaO4S |
| Solubility | ≥18.57 mg/mL in H2O; ≥73.6 mg/mL in DMSO; ≥75.2 mg/mL in EtOH |
| Chemical Name | sodium;(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Canonical SMILES | CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with IC50 value of 1.8 μg/ml [1].
Ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. Transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].
InE. coli 146cells treated with ether, Ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. InE. coli 146cells, the minimal inhibitory concentration (MIC) of Ampicillin was 3.1 μg/ml [1]. InE. coliandS. typhi, Ampicillin and Epicillin at concentrations close to MIC values killed bacteria at slower rates than Amoxycillin [2].
In experimental mouse infections, oral or subcutaneous treatment of Ampicillin at the dose of 0.2 ml/20 g was significantly more effective than Epicillin and Amoxycillin against the majority of infections [2].
References:
[1]. Moore B A, Jevons S, Brammer K W. Inhibition of transpeptidase activity in Escherichia coli by thienamycin. Antimicrobial Agents and Chemotherapy, 1979, 15(6): 831-833.
[2]. Basker M J, Gwynn M N, White A R. Comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. Chemotherapy, 1979, 25(3): 170-180.
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