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Teneligliptin hydrobromide hydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Teneligliptin hydrobromide hydrate图片
CAS NO:1572583-29-9
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
Teneligliptin hydrobromide hydrate 是一种有效的 DPP-4 抑制剂，竞争性抑制人血浆、大鼠血浆和重组人 DPP-4 的活性，IC50 值约为 1 nM。
Cas No.1572583-29-9
别名氢溴酸替格列汀水合物,MP-513 hydrobromide hydrate
Canonical SMILESO=C([C@H]1NC[C@@H](N2CCN(C3=CC(C)=NN3C4=CC=CC=C4)CC2)C1)N5CSCC5.[x H2O].[5/2 HBr]
分子式C22H30N6OS
分子量426.58
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Teneligliptin hydrobromide hydrate is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202.