Nifuratel

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Nifuratel

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

4936-47-4

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	285.28
Cas No.	4936-47-4
Formula	C₁₀H₁₁N₃O₅S
Synonyms	NF 113;SAP 113;Methylmercadone
Solubility	Soluble in DMSO
Chemical Name	5-(methylsulfanylmethyl)-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
Canonical SMILES	CSCC1CN(C(=O)O1)N=CC2=CC=C(O2)[N+](=O)[O-]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Description: IC50 Value: 0.125-1 μg/mL(MIC, A. vaginae) [1] Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp. in vitro: In vitro, nifuratel is able to inhibit the growth of A. vaginae, with a MIC range of 0.125-1 μg/mL; it is active against G. vaginalis and does not affect lactobacilli [1]. in vivo: Patients were randomized to receive a 2-week course of bismuth subcitrate (8 mg/kg/day, q.d.s.), amoxicillin (50 mg/kg/day, q.d.s.), with either nifuratel (15 mg/kg/day, q.d.s.) or furazolidone (10 mg/kg/day, q.d.s.), plus omeprazole (0.5 mg/kg, once daily) [2]. Toxicity: There were no serious adverse reactions and were no withdrawals due to any side-effects. All of side-effects were self-limiting (dark stools, urine discoloration, blackening of the tongue, and others) [3]. Clinical trial: N/A

试验操作

细胞实验 [1]：
细胞系	阴道阿托波氏菌，阴道嗜血杆菌，乳酸杆菌
溶解方法	在DMSO中是可溶的。为了获得更高的浓度，可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。
反应条件	0.125 μg/ml～0.5 μg/ml
应用	在体外，nifuratel能够抑制阴道阿托波氏菌的生长，MIC范围为0.125-1μg/ mL。它对阴道嗜血杆菌有活性，不影响乳酸杆菌。这些观察结果表明nifuratel可能是细菌性阴道病最有效的治疗剂。
References: [1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40. doi: 10.2174/157488412799218824. PMID: 22082330; PMCID: PMC3362959.