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Filipin II
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Filipin II图片
CAS NO:38620-77-8
包装与价格：
包装价格(元)
500μg电议
2.5mg电议

产品介绍

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex.

Cas No.38620-77-8
化学名4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-hexyl-17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,23E,25E-pentaen-2-one
Canonical SMILESO[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@H](CCCCCC)[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O
分子式C35H58O10
分子量638.8
溶解度Soluble in DMSO, DMF, Ethanol, Methanol
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]

Reference:
[1]. Bergy, M.E., and Eble, T.E. The filipin complex. Biochemistry 7(2), 653-659 (1968).
[2]. Balcavage, W.X., Beale, M., Chasen, B., et al. Effect of filipin on rat-liver and yeast mitochondria. Biochim. Biophys. Acta. 162(4), 525-532 (1968).
[3]. Sessa, G., and Weissmann, G. Effects of four components of the polyene antibiotic, filipin, on phospholipid spherules (liposomes) and erythrocytes. J. Biol. Chem. 243(16), 4364-4371 (1968).