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Emactuzumab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1448221-67-7
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Emactuzumab (RG 7155) 是一种特异性单克隆抗体,可抑制集落刺激因子 1 受体 (CSF1R) 的激活。Emactuzumab 对 CSF-1R 具有高亲和力,Ki 值为 0.2 nM,可阻断 CSF-1R 二聚化。Emactuzumab 可用于多种疾病的研究,如弥漫型腱鞘巨细胞瘤(dt-GCT)。
Cas No.1448221-67-7
别名RG 7155; RO 5509554
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.2 nM (CSF-1R)[2]

Emactuzumab(RG 7155) is a specificmonoclonal antibodythat inhibits colonystimulating factor 1 receptor(CSF1R)activation. Emactuzumab has high affinity for CSF-1R withKivalue of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT)[1][2].

Emactuzumab (RG 7155) binds to human and cynomolgus CSF-1R with high affinity (Kd= 0.2 nM) to blocks CSF-1R dimerization[2].
RG7155 (0-10 μg/mL, 7 days) potently inhibited the viability of CSF-1-differentiated macrophages with an IC50of 0.3 nM by inducing cell death[2].
RG7155 (30 μg/mL, 6 days) induces cell death of in vitro-differentiated human M2-like macrophages[2].

Cell Viability Assay[2]

Cell Line:CSF-1 and/or GM-CSF Macrophages
Concentration:0-10 μg/mL
Incubation Time:7 days
Result:Resulted cell death of CSF-1-differentiated macrophages.

Emactuzumab(RG 7155) (i.v.; 0.1、1、10、30 and 100 mg/kg; once) increases CSF-1 concentration in nonhuman primates' peripheral blood[2].
RG7155 (i.v.; 0, 30, and 100 mg/kg; once weekly; for 2 weeks) depletes CSF-1R+CD163+macrophages in vivo[2].

Animal Model:cynomolgus monkeysMacaca fascicularis[2]
Dosage:0.1, 1, 10, 30 and 100 mg/kg (male cynomolgus monkeys)
0, 30, and 100 mg/kg (male and female cynomolgus)
Administration:i.v., once (male cynomolgus monkeys)
i.v., once weekly, for 2 weeks(male and female cynomolgus)
Result:Increased CSF-1 concentration in serum.
Efficiently reduced CSF-1R and CD68+163+macrophages in the liver (Kupffer cells) and colon of cynomologus monkeys.