| CAS NO: | 119478-55-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Molecular Weight (MW) | 453.48 |
|---|---|
| Formula | C19H20FN3O3.CH4O3S |
| CAS No. | 119478-55-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: <1 mg/mL |
| Water: 91 mg/mL (200.7 mM) | |
| Ethanol: <1 mg/mL | |
| Solubility (In vivo) | Saline: 30 mg/mL |
| Synonyms | Synonym: CP 76,136-27; CP-76,136-27; Danofloxacin monomethanesulfonate. Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-((1S,4S)-5-methyl-2,5-diazabicyclo(2.2.1)hept-2-yl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate InChi Key: APFDJSVKQNSTKF-FXMYHANSSA-N InChi Code: InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1 SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O.CS(=O)(O)=O |
| In Vitro | In vitro activity: Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml. |
|---|---|
| In Vivo | Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay. |
| Animal model | Mice model |
| Formulation & Dosage | Dissolved in 2.5% or 5% water solution; 0-10 mg/kg; p.o or s.c. |
| References | J Vet Pharmacol Ther. 1991 Dec;14(4):400-10; J Med Chem. 1992 Feb 21;35(4):611-20. |
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