Blosozumab (LY2541546) 是一种抗人 sclerostin (SOST) 的抗体抑制剂。Blosozumab 可刺激骨形成并减少骨吸收。Blosozumab 可用于骨质疏松症的研究。
| Cas No. | 1132758-87-2 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Blosozumab (LY2541546) is an anti-Humansclerostin (SOST)antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2]. Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].
| Animal Model: | Sprague-Dawley rats[2] | | Dosage: | 1, 10, and 100 mg/kg | | Administration: | Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study) | | Result: | Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg. |
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