您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > 7-Chlorokynurenic acid sodium salt
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
7-Chlorokynurenic acid sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7-Chlorokynurenic acid sodium salt图片
CAS NO:1263094-00-3
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) 是 N-甲基-D-天冬氨酸 (NMDA) 受体的甘氨酸 B 共激动剂位点的有效选择性拮抗剂 (IC50=0.56 μM)。
Cas No.1263094-00-3
别名7-氯犬尿喹啉酸钠盐,7-CKA sodium salt
化学名sodium 7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylate
Canonical SMILESClC1=CC(N2)=C(C(C=C2C([O-])=O)=O)C=C1.[Na+]
分子式C10H5ClNNaO3
分子量245.59
溶解度Soluble to 100 mM in sterile water
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7-Chlorokynurenic acid sodium salt is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery[1][2].

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].

References:
[1]. Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
[2]. Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
[3]. Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.