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KS 176
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KS 176图片
CAS NO:1253452-78-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
KS 176 是一种有效的选择性乳腺癌耐药蛋白 (BCRP) 多药转运蛋白抑制剂(在 Pheo A 和 Hoechst 33342 测定中,IC50 值分别为 0.59 和 1.39 μM)。对 P-gp 或 MRP1 没有抑制活性。
Cas No.1253452-78-6
化学名N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
Canonical SMILESOCCC1=CC=C(NC(C2=CC=CC=C2NC(C3=CC=C(N(=O)=O)C=C3)=O)=O)C=C1
分子式C22H19N3O5
分子量405.4
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference.

References:
[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505.