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CMPDA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CMPDA图片
CAS NO:380607-77-2
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
CMPDA 是一种 AMPA 受体的正变构调节剂，对 GluA2i/GluA2o 受体的 EC50 值为 45.4 ± 4.2 nM/63.4 ± 5.6 nM。
Cas No.380607-77-2
化学名N,N'-(1,4-phenylenebis(ethane-2,1-diyl))bis(propane-2-sulfonamide)
Canonical SMILESCC(S(NCCC1=CC=C(CCNS(C(C)C)(=O)=O)C=C1)(=O)=O)C
分子式C16H28N2O4S2
分子量376.53
溶解度DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.IC50 value: 45.4 ± 4.2 nM/63.4 ± 5.6 nM(GluA2i/GluA2o) [1]Target: AMPAR modulatorCMPDA was nearly equipotent at modulating the two isoforms of GluA2 receptors, whereas CMPDB displayed a modest preference for the flip splice variant. Similar to CX614, CMPDA slowed the rate of deactivation of GluA2o receptors approximately 2-fold but had no effect on GluA2i receptor deactivation [1].

References:
[1]. Timm DE, et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol Pharmacol. 2011 Aug;80(2):267-80.