Eact 是 TMEM16A 的选择性和有效激活剂，直接激活感觉伤害感受器中的 TRPV1 通道并产生瘙痒、急性伤害感受和热过敏。
| Cas No. | 461000-66-8 |
| 别名 | 3,4,5-三甲氧基-N-(2-甲氧基乙基)-N-(4-苯基-2-噻唑基)苯甲酰胺 |
| 化学名 | 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide |
| Canonical SMILES | COCCN(C1=NC(C2=CC=CC=C2)=CS1)C(C3=CC(OC)=C(OC)C(OC)=C3)=O |
| 分子式 | C22H24N2O5S |
| 分子量 | 428.5 |
| 溶解度 | <42.85mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50= 3μM). Also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50= 11.6 μM). Ca2+-independent. Displays no effect on CFTR Cl-or ENaC Na+conductance. Stimulates submucosal gland secretion in human bronchi. |
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