| CAS NO: | 113777-40-5 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | White crystalline solid |
| Storage | Store at RT |
| M.Wt | 422.95 |
| Cas No. | 113777-40-5 |
| Formula | C22H30N2O4·HCl |
| Solubility | Soluble to 5 mM in H2O |
| Chemical Name | 8-(4-(((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)amino)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
| Canonical SMILES | O=C(N1CCCCNCC2COC3=CC=CC=C3O2)CC4(CC1=O)CCCC4.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
MDL 72832盐酸盐是一种强效的和选择性的5-HT1A受体的配体,pIC50值为9.1 [1].
5-T1A受体是一种内源性神经递质5-羟色胺(5-HT)的G蛋白偶联受体,介导抑制性神经递质.
MDL 72832盐酸盐是一种强效的和选择性的5-HT1A受体的配体[1].另外,MDL 72832对5-HT1C 和5-HT1D受体也具有亲和力,pKD值分别为6.32和6.34[1].
大鼠中,MDL 72832抑制8-OH-DPAT诱发的心血管效应.在豚鼠体内,8-OH-DPAT浓度依赖性地抑制场刺激的豚鼠回肠收缩.然而,MDL 72832抑制8-OH-DPAT诱发的神经元抑制.MDL 72832是5-HT1A受体的配体,具有拮抗剂和激动剂的混合性质[1].在未进满食的大鼠体内,(+) -MDL 72832 (1.0 mg/kg) 刺激食物摄入,(-) -MDL 72832 (0.03 mg/kg)显著增加食物摄入[2].在大鼠中,MDL 72832增加突触后5-HT1A受体介导的低温症,且其具有激动剂特性[3].
参考文献：
[1]. Mir AK, Hibert M, Tricklebank MD, et al. MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. Eur J Pharmacol, 1988, 149(1-2): 107-120.
[2]. Neill JC, Cooper SJ. MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake. Eur J Pharmacol, 1988, 151(2): 329-332.
[3]. Millan MJ, Rivet JM, Canton H, et al. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. J Pharmacol Exp Ther, 1993, 264(3): 1364-1376.
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