| CAS NO: | 1135278-41-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | White solid |
| Storage | Store at RT |
| M.Wt | 361.91 |
| Cas No. | 1135278-41-9 |
| Formula | C21H27NO2·HCl |
| Solubility | Soluble in DMSO |
| Chemical Name | (S)-1-(2-ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol hydrochloride |
| Canonical SMILES | O[C@H](COC1=CC=CC=C1CC)CN[C@H]2CCCC3=CC=CC=C23.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
R 59230A hydrochloride is a selective and potent antagonist of β3adrenoceptor, with IC50 values being 40, 408, and 648 nM for β3, β1, and β2adrenergic receptors, respectively. β3adrenoceptor, predominately located in adipose tissue, is mainly responsible for the regulation of lipolysis and thermogenesis. In addition, β3adrenoceptor has also been found to be involved in different tumor conditions, such as neuroblastoma, via the regulation of the bioactive lipid sphingosine 1-phosphate metabolism and signaling.
References:
1. Nisoli E, Tonello C, Landi M, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Molecular Pharmacology, 1996, 49(1): 7-14.
2. Kanzler SA, Januario AC, Paschoalini MA. Involvement of β3-adrenergic receptors in the control of food intake in rats. Brazilian Journal of Medical and Biological Research, 2011, 44(11): 1141-1147.
3. Bruno G, Cencetti F, Pini A, et al.β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene, 2020, 39(2): 368-384.
4. Bexis S, Docherty JR. Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. British Journal of Pharmacology, 2009, 158(1): 259-266.
| Cell experiment:[3] | |
Cell lines | Neuroblastoma cell lines, including murine Neuro-2A, as well as human BE(2)C and SK-N-BE(2) |
Reaction Conditions | 100 nM ~ 50 μM SR 59230A hydrochloride for 24 h incubation |
Applications | SR 59230A hydrochloride was able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) neuroblastoma cell lines. |
| Animal experiment:[4] | |
Animal models | Male C-57BL6J wild-type mice, 22-35 g |
Dosage form | 0.5 or 5 mg/kg Injected subcutaneously 30 min prior to the subcutaneous injection of MDMA |
Applications | At a low concentration of 0.5 mg/kg, SR 59230A hydrochloride produced a small but significant attenuation of the slowly developing hyperthermia to methylenedioxymethamphetamine (MDMA). At a high concentration of 5 mg/kg, SR 59230A hydrochloride revealed a significant and marked early hypothermic reaction to MDMA. |
Note | The technical data provided above is for reference only. |
References: 1. Nisoli E, Tonello C, Landi M, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes. Molecular Pharmacology, 1996, 49(1): 7-14. 2. Kanzler SA, Januario AC, Paschoalini MA. Involvement of β3-adrenergic receptors in the control of food intake in rats. Brazilian Journal of Medical and Biological Research, 2011, 44(11): 1141-1147. 3. Bruno G, Cencetti F, Pini A, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. Oncogene, 2020, 39(2): 368-384. 4. Bexis S, Docherty JR. Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse. British Journal of Pharmacology, 2009, 158(1): 259-266. | |
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