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UP202-56
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UP202-56图片
CAS NO:163838-04-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
UP202-56是一种腺苷类似物,是一种腺苷能激动剂。
Cas No.163838-04-8
Canonical SMILESO[C@H]1[C@@H](O[C@H](C(CC2CC2)=O)[C@H]1O)N3C4=C(C(NCCC5=CN(CC6=C(C=CC(C)=C6)C)C7=C5C=C(C)C=C7)=NC=N4)N=C3
分子式C34H38N6O4
分子量594.7
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

UP202-56 is an adenosine analogue, which is an adenosinergic agonist.

The effects of oral administration of UP202-56, an adenosine analogue, are assessed on carrageenan-induced spinal c-Fos protein expression and peripheral oedema. Oral UP202-56 (10, 30 or 50 mg/kg) dose-dependently reduces the number of carrageenan-induced c-Fos like immunoreactivity (c-Fos-LI) neurons (r=0.931. P<0.0001), with the highest dose of UP202-56 producing 72±4% reduction of the total number of carrageenan-induced spinal c-Fos-LI neurons, and 12±3% and 33±6% of reduction of control carrageenan oedema at paw and ankle levels, respectively. UP202-56 dose-dependently reduces the spinal c-Fos protein expression in carrageenan model of inflammatory pain[1]. UP202-56 is an adenosinergic agonist[2].

[1]. Honoré P, et al. UP 202-56, an adenosine analogue, selectively acts via A1 receptors to significantly decrease noxiously-evoked spinal c-Fos protein expression. Pain. 1998 Apr;75(2-3):281-93. [2]. Camborde, Francois, et al. PHARMACEUTICAL COMBINATION WITH ANALGESIC ACTIVITY, CONTAINING AN ADENOSINERGIC AGONIST AND A COMPOUND SELECTED FROM OPIATES, BENZODIAZEPINES AND NMDA ANTAGONISTS. Patent Application WO/1999/029347.