CAY10502 是一种有效的钙依赖性胞质磷脂酶 A2 α (cPLA2α) 抑制剂，对分离酶的 IC50 为 4.3 nM。
| Cas No. | 888320-29-4 |
| Canonical SMILES | O=C(COC1=CC=C(OCCCCCCCCCC)C=C1)CN2C3=CC=C(C(O)=O)C=C3C(C(OC)=O)=C2 |
| 分子式 | C30H37NO7 |
| 分子量 | 523.6 |
| 溶解度 | DMF: 20 mg/ml,DMF:PBS (pH 7.2)(1:1): 0.5 mg/ml,DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. |
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