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Cholic Acid 7-sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cholic Acid 7-sulfate图片
CAS NO:60320-05-0
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
Cholic acid 7-sulfate (7-Sulfocholic acid) 是胆酸的代谢物,是武田 G 蛋白受体 5 (TGR5) 激动剂。
Cas No.60320-05-0
别名胆酸7-硫酸盐,7-Sulfocholic acid
化学名(3α,5β,7α,12α)-3,12-dihydroxy-7-(sulfooxy)-cholan-24-oic acid
Canonical SMILESC[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](OS(O)(=O)=O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
分子式C24H40O8S
分子量488.6
溶解度0.3mg/mL in DMSO, 1mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2]

Reference:
[1]. Alnouti, Y. Bile acid sulfation: A pathway of bile acid elimination and detoxification. Toxicological Sciences 108(2), 225-246 (2009).
[2]. Zhang, Y., and Klaassen, C.D. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J. Lipid Res. 51(11), 3230-3242 (2010).