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Hydroxy Pioglitazone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hydroxy Pioglitazone图片
CAS NO:146062-44-4
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
羟基吡格列酮（Hydroxypioglitazone），吡格列酮的代谢产物。
Cas No.146062-44-4
别名羟基匹格列酮,Hydroxypioglitazone
Canonical SMILESCC(O)C1=CN=C(CCOC2=CC=C(CC3SC(NC3=O)=O)C=C2)C=C1
分子式C19H20N2O4S
分子量372.4
溶解度DMF: soluble,DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50 of 680 nM[1].

References:
[1]. Mosure SA,et al. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. J Med Chem. 2019 Feb 28;62(4):2008-2023.