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Oroxin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Oroxin A图片
CAS NO:57396-78-8
包装:20mg
市场价:1425元

产品介绍
Oroxin A 是乙醇-水 Oroxylum indicum (L.
Cas No.57396-78-8
别名千层纸苷A
化学名5,6-dihydroxy-2-phenyl-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
Canonical SMILESO[C@H]1[C@H](OC2=C(O)C(O)=C(C(C=C(C3=CC=CC=C3)O4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
分子式C21H20O10
分子量432.38
储存条件Store at 2-8℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].

Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells[1].

References:
[1]. Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34.
[2]. He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27(3):204-15.