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JE(MCP-1),murine recombinant protein
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
JE(MCP-1),murine recombinant protein图片
包装与价格：
包装价格(元)
10ug电议
50ug电议
1mg电议

产品介绍

描述

Gene ID:20296Accession #:P10148
Alternate Names:Small inducible cytokine A2, CCL2, Monocyte chemotactic protein 1, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte secretory protein JE, HC11, chemokine (C-C motif) ligand 2, MCP1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, GDCF-2 HC11.
Source:Escherichia Coli.M.Wt:13.8 kDa
Appearance:Lyophilized proteinStorage:Store at -20°C
Formulation:Sterile filtered and lyophilized with no additives.
Solubility:Reconstitute in H2O to a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use.
Shipping Condition:Blue ice.Handling:Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.

资料参考

JE (MCP-1), also known as chemokine (C-C motif) ligand 2 (CCL2), is a member of the CC chemokine family that is a chemotactic agent for mononuclear cells. JE (MCP-1) is produced by endothelial cells, smooth muscle cells, and monocytes in response to several atherogenic stimulants such as interleukin-1β (IL-1β), platelet derived growth factor (PDGF), CD40 ligand and oxidized low density lipoprotein. CCL2 induces histamine release by basophils, and enzyme and cytokine release by monocytes, NK cells and lymphocytes. CCL2-mediated recruitment of monocytes to sites of inflammation plays important roles in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.

 The murine JE (MCP-1) cDNA encodes a 148 aa protein with a 23 aa signal sequence. Human CCL2 induces a limited response in rodent cells, and mouse CCL2 has full activity on human cells. Recombinant murine JE (MCP-1) is a 13.8 kDa protein containing 125 amino acid residues.

生物活性

Determined by measuring the dose dependent chemotaxis with human THP-1 cells.
ED501-10 ng/ml.