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Amyloidβ-Peptide(1-42)(human)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Amyloidβ-Peptide(1-42)(human)图片
CAS NO:107761-42-2
包装:1mg
市场价:3432元

产品介绍

化学性质

StorageStore at -20°C
M.Wt4514.08
Cas No.107761-42-2
FormulaC203H311N55O60S
Solubilityinsoluble in H2O; insoluble in EtOH; ≥40.5 mg/mL in DMSO
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Amyloidβ-Peptide (1-42) (Aβ42) human is a 42-amino acid peptide that plays a key role in the pathogenesis of Alzheimer disease (AD) [1].

The main deleterious effects in the pathogenesis are probably regulated by Aβ42, which acts as a repressor or activator of gene transcription causing further synaptic function damage and neuronal degeneration [2].

Aβ42 reduced the viability of SH-SY5Y cells to 65% when it rose to 2.5 μM. Using the chromatin immunoprecipitation (ChIP) and qRT-PCR assays, treatment of SH-SY5Y cells with Aβ42 associated peptide with bothLRP1andKAI1promoters and increasedAPPmRNA levels, while the nontoxic Aβ42 G33A peptide, as a control group which presents in the nucleus abundantly, did not have any influence on mRNA expression. The exclusive increase of transcription and expression of its precursor geneAPPwas found with the treatment of Aβ42, compared with several different lengths of peptides [1].

Aβ42 is regarded as an important role in modulating the function of voltage-gated Ca2+- and K+-channels of the surface neuronal membranes. Application of Aβ42 with desired concentrations (1 to 10 μM) in the perfusing medium had no impact on delayed rectifier K+-current and leakage current, while enhanced inactivation of Ca2+-current and blocked Ca2+-dependent K+-current [3].

Reference:

[1] Barucker C, Harmeier A, Weiske J, et al. Nuclear Translocation Uncovers the Amyloid Peptide Aβ42 as a Regulator of Gene Transcription. The journal of biological chemistry, 2014, 289(29): 20182-20191.

[2] Hardy J and Selkoe D J. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science, 2002, 297(5580): 353-356.

[3] Solntseva E I, Bukanova J V, Marchenko E V, et al. Impact of Amyloid-β Peptide (1-42) on Voltage-Gated Ion Currents in Molluscan Neurons. Bulletin of experimental biology and medicine, 2011, 151(6): 671-674.