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Acetyl Podocarpic Acid Anhydride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Acetyl Podocarpic Acid Anhydride图片
CAS NO:344327-48-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt614.8
Cas No.344327-48-6
FormulaC38H46O7
SynonymsAPD
Solubility≤1mg/ml in dimethyl formamide
Chemical Name6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, anhydride
Canonical SMILESCC(=O)Oc1ccc2CC[C@H]3[C@](C)(CCC[C@]3(C)c2c1)[C@@H](=O)O[C@H](=O)[C@@]1(C)CCC[C@]2(C)c3cc(ccc3CC[C@@H]12)OC(=O)C
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Target: LXR

ED50: 1 nM

Acetyl podocarpic acid anhydride (APD) is a kind of potent, semi-synthetic agonist of liver X receptor (LXR), which was derived from the extracts of the mayapple [1].

The liver X receptor is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the farnesoid X receptor (FXR), Peroxisome proliferator-activated receptor (PPARs) and retinoid X receptor (RXR). LXRs are key regulators involved in fatty acid, cholesterol, and glucose homeostasis. APD could inhibit the overall absorption of cholesterol by increasing the efflux of cholesterol from enterocytes, with the ED50 value of 1 nM [2].

In Vitro: In a cell-free assay of receptor activation, APD could cause LXR to bind to SRC-1, with a much more potentiality than 22-(R)-hydroxycholesterol. Besides, in THP-1 human primary hepatocytes, and Caco-2 cells, APD could significantly increase the mRNA level of ABCA1, which was regulated by LXR [2].

In Vivo: no data available.

Clinical trial: no data available.

References:
[1] Costet P, Luo Y, Wang N, et al.  Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor[J]. Journal of Biological Chemistry, 2000, 275(36): 28240-28245.
[2] Sparrow C P, Baffic J, Lam M, et al.  A potent synthetic LXR agonist is more effective than cholesterol-loading at inducing ABCA1 mRNA and stimulating cholesterol efflux[J]. Journal of Biological Chemistry, 2002, 277(12): 10021-10027.