| CAS NO: | 85075-82-7 |
| 包装 | 价格(元) |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| 25mg (solution) | 电议 |
| Physical Appearance | A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 309.5 |
| Cas No. | 85075-82-7 |
| Formula | C20H39NO |
| Synonyms | OEtA,N-Ethyloleamide |
| Solubility | ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
| Chemical Name | N-ethyl-9Z-octadecenamide |
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)NCC |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity [1].
Fatty acid amide hydrolase (FAAH) is an integral membrane hydrolase and a member of the serine hydrolase family of enzymes. In vitro, FAAH has esterase and amidase activity. In vivo, FAAH is the principal catabolic enzyme for the fatty acid amides (FAAs).
Oleoyl Ethyl Amide (OEtA) is a potent fatty amide acyl hydrolase (FAAH) inhibitor. In rat brain homogenates, Oleoyl Ethyl Amide inhibited FAAH activity with IC50 value of 5.25 nM, but did not bind to CB1 or CB2 receptors, or inhibit acidic PEAase. Oleoyl Ethyl Amide is a potent and selective FAAH inhibitor with potential analgesic and anxiolytic activity [1].
In Sprague-Dawley rats, subcutaneous injections of OEtA (0.3 mg/kg) for 2 weeks increased values of micturition intervals (MI) and volumes (MV), bladder capacity (BC), threshold pressure, and flow pressure. OEtA altered sensory urodynamic parameters and reduced bladder overactivity [2].
References:
[1]. Vandevoorde, S.,Lavand'homme, P.,Fowler, C.J., et al. Oleoylethylamide, an analgesic FAAH inhibitor which modulates endogenous anandamide, oleoylethanolamide, and 2-arachidonoylglycerol levels in the brain. 14th Annual Symposium on the Cannabinoids 15-15 (2004).
[2]. Gandaglia G, Strittmatter F, La Croce G, et al. The fatty acid amide hydrolase inhibitor oleoyl ethyl amide counteracts bladder overactivity in female rats. Neurourol Urodyn. 2014 Nov;33(8):1251-8.
m.cnreagent.com