Hexanolamino PAF C-16

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

137566-83-7

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A lyophilized powder
Storage	Store at -20°C
M.Wt	579.8
Cas No.	137566-83-7
Formula	C₃₀H₆₂NO₇P
Solubility	≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
Chemical Name	1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl(N,N,N-trimethyl)hexanolamine
Canonical SMILES	CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCCCCCC[N+](C)(C)C)([O-])=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Hexanolamino PAF C-16 is a PAF analog with PAF agonist/antagonist properties.

Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].

Hexanolamino PAF C-16, a PAF analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. In human monocyte-derived macrophages, Hexanolamino PAF C-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (H202) in response to PAF [1]. In both rabbit platelets and guinea-pig macrophages, Hexanolamino PAF C-16 acted as a partial agonist [2].

References:
[1]. Rouis M, Nigon F, Chapman MJ. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun. 1988 Nov 15;156(3):1293-301.
[2]. Stewart AG, Grigoriadis G. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat. 1991 Nov;4(3):299-308.