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γ-Linolenic Acid methyl ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
γ-Linolenic Acid methyl ester图片
CAS NO:16326-32-2
包装与价格:
包装价格(元)
50mg (solution)电议
100mg (solution)电议
250mg (solution)电议
1g (solution)电议

产品介绍

化学性质

Physical AppearanceA solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
StorageStore at -20°C
M.Wt292.5
Cas No.16326-32-2
FormulaC19H32O2
SynonymsMethyl GLA,Methyl γ-Linolenate
Solubility≤100mg/ml in DMSO;100mg/ml in dimethyl formamide
Chemical Name6Z,9Z,12Z-octadecatrienoic acid, methyl ester
Canonical SMILESCCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.

LTB 4, a potent neutrophil chemoattractant, is present at high concentrations in psoriatic lesions, bronchoalveolar lavage in asthmatics and rectal dialysates in patients with inflammatory bowel disease.

In vitro: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM [1].

In vivo: In an in-vivo model of LTB4-induced bronchoconstriction, ricinelaidic acid andγ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Yagaloff, K. A.,Franco, L.,Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukotrienes and Essential Fatty Acids 52, 293-297 (1995).