| CAS NO: | 9076-44-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 607.7 |
| Cas No. | 9076-44-2 |
| Formula | C31H41O6N7 |
| Solubility | ≤10mg/ml in DMSO |
| Chemical Name | (2R,6R,9R,12R)-6-((R)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2,12-dibenzyl-9-isobutyl-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid |
| Canonical SMILES | O=C(O)[C@H](NC(N[C@H]([C@H]1CCN=C(N)N1)C(N[C@H](CC(C)C)C(N[C@H](CC2=CC=CC=C2)C=O)=O)=O)=O)CC3=CC=CC=C3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Ki: 9.36 and 13.1 nM for chymotrypsin and chymase, respectively
Chymostatin is a chymotryptase-like serine proteases inhibitor.
Serine proteases are enzymes cleaving peptide bonds, in which serine plays as the nucleophilic amino acid. Serine proteases can be classfied into two broad categories: chymotrypsin-like (trypsin-like) or subtilisin-like.
In vitro: Chymostatin was found to be a potent inhibitor of human leucocyte chymotrypsin-like protease. Its affinity to the leucocyte protease was found to be much higher than its affinity to bovine pancreatic alpha-chymotrypsin. Chymsotatin also showed a weak inhibitory effect on the activity of human leucocyte elastase. In addition, the preincubation of chymostatin with 35SO2-4-labeled cartilage before the addition of the human chymotrypsin-like protease to the tissue could also inhibit 35SO2-4 release [1].
In vivo: The effect of chymostatin on C57BL/6J-dy dystrophic mice was studied. The locomotor activity of normal mice markedly increased, attaining a plateau at 8 weeks of age. Serum levels of creatine phosphokinase were much higher in dystrophic mice when compared with normal mice, and dystrophic mice also showed a reduced muscle protein content. When 3-week-old dystrophic mice received chymostatin at 1 mg/kg, the decrease in locomotor activity could be retarded, serum enzyme levels significantly decreased, and muscle protein content also obviously increased. In addition, the survival time of chymostatin-treated dystrophic mice was prolonged [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Feinstein, G. ,Malemud, C.J., and Janoff, A. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim.Biophys.Acta. 429(3), 925-932 (1976).
[2] Komatsu K, Matsui A, Satoh S. Beneficial effect of chymostatin on dystrophic mice. Exp Neurol. 1986 Jul;93(1):110-6.
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