| CAS NO: | 1143-70-0 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 228.20 |
| Cas No. | 1143-70-0 |
| Formula | C13H8O4 |
| Solubility | ≥22.8 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 3,8-dihydroxy-6H-benzo[c]chromen-6-one |
| Canonical SMILES | OC1=CC(C2=O)=C(C3=C(O2)C=C(O)C=C3)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Urolithin A is a microflora-derived metabolite [1].
Urolithin A is a natural food metabolite that stimulates mitophagy and reduces the accumulation of dysfunctional mitochondria with age, thus maintaining mitochondrial biogenesis and respiratory capacity in cells [1]. Urolithin A is the most active and effective gut metabolite that acts as a potent anti-inflammatory and anti-oxidant agent [2].
In CD4+ T cells, treatment of murine CD4+ T cells with Urolithin A (10 μM, 3 days) significantly blunted store operated Ca2+ entry (SOCE), which was accompanied by significant downregulation of STIM1/2 and Orai1 transcript levels and protein abundance. In addition, urolithin A treatment (5, 10, 20, 50 μM) further increased miR-10a-5p abundance in CD4+ T cells, in a dose-dependent manner [2].
In healthy, sedentary elderly individuals, 4 weeks of oral treatment with urolithin A at doses of 500 mg and 1000 mg modulated plasma acylcarnitines and skeletal muscle mitochondrial gene expression, with favourable safety profiles [1].
References:
[1]. Pénélope A. Andreux, Blanco-Bose W, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 2019, 1: 595-603.
[2]. Zhang S, Al-Maghout T, Cao H, et al. Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p. Frontiers in Immunology, 2019, 10(1737): 1-12.
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