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Puerarin(Kakonein)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Puerarin(Kakonein)图片
CAS NO:3681-99-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)416.38
FormulaC21H20O9
CAS No.3681-99-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 86 mg/mL (206.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: 7-hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one

InChi Key: HKEAFJYKMMKDOR-VPRICQMDSA-N

InChi Code: InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

SMILES Code: O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC=C13

SynonymsKakonein; NPI-031G; NPI031G; NPI 031G; Puerarin
实验参考方法
In Vitro

In vitro activity: Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Pueraria is employed clinically to treat cardiovascular diseases in China. Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2.

In VivoIn hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. LD50: Mice 738mg/kg (i.v.)
Animal modelRats
Formulation & Dosage300 mg/kg/day, p.o.
References

Pharmacol Biochem Behav. 2003 Jun;75(3):619-25; Life Sci. 2006 Jun 20;79(4):324-30; Cancer Lett. 2006 Jul 8;238(1):53-60.