您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Dictamnine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dictamnine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dictamnine图片
CAS NO:484-29-7
包装:20mg
市场价:1491元

产品介绍
Dictamnine (Dictamnine) 具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力;据报道,一种天然植物产品对细菌和真菌具有抗菌活性。
Cas No.484-29-7
别名白鲜碱; Dictamnine; Dectamine
化学名4-methoxyfuro[2,3-b]quinoline
Canonical SMILESCOC1=C2C=COC2=NC3=CC=CC=C31
分子式C12H9NO2
分子量199.21
溶解度≥ 19.9mg/mL in DMSO
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi.IC50 value:Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2].

References:
[1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.
[2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.