| CAS NO: | 52-39-1 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 360.44 |
| Cas No. | 52-39-1 |
| Formula | C21H28O5 |
| Solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde |
| Canonical SMILES | O=C1CC[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(CC[C@@H]4C(CO)=O)[H])C([H])=O)O)[H])[H])=C1)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance[1].
In vascular smooth muscle cells, aldosterone inhibits nitrite production in a dose-dependent manner, which is induced by interleukin-1β (IL-1β). Aldosterone inhibits mRNA expression of NO synthase. And reduce the accumulation of nitric oxide synthase protein. In conclusion, aldosterone inhibits NO synthesis in vascular smooth muscle cells under IL-1β stimulated conditions[2].
Aldosterone (0.72 mg/kg/day, 14 days) caused a slight increase in blood pressure in male mice (14 mmHg). Aldosterone can also increase the production of superoxide in the cerebral arteries of mice and promote mRNA expression of chemokine (C-C motif) ligand 7 (CCL7), CCL8 and IL-1β in the brain[3].
References:
[1]. Agarwal M K, Mirshahi M. General overview of mineralocorticoid hormone action. Pharmacology & Therapeutics, 2000, 84(3): 273-326.
[2]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995, 290(2): 69-73.
[3]. Dinh Q N, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res, 2016, 1637: 146-153.
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