| CAS NO: | 58-22-0 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 150mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 288.42 |
| Cas No. | 58-22-0 |
| Formula | C19H28O2 |
| Solubility | insoluble in H2O; ≥36.3 mg/mL in EtOH; ≥47.6 mg/mL in DMSO |
| Chemical Name | (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
| Canonical SMILES | O=C1CC[C@]2(C)[C@@]3([H])CC[C@@]4(C)[C@](CC[C@@H]4O)([H])[C@]3([H])CCC2=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Testosterone, the major androgen in males, acts by binding to the androgen receptor (AR), with an EC50 of 0.66 nM [1].
Testosterone is essential for the maintenance of spermatogenesis by binding to the AR, which is expressed in different cell types of the testis such as Sertoli cells and sperm cells [2]. Testosterone has also been suggested to play a role in mediating biological processes associated with bone metabolism [3].
In vitro incubation with testosterone (0, 2, 4, or 6 ng/mL) decreased the post-thaw acrosome integrity of ram (Ovis aries) sperm (from 68.1 ± 6.3% to 49.6 ± 3.9%) [2]. In RAW264.7 cells stimulated by receptor activator of nuclear factor kappa-Β ligand (RANKL), testosterone (1, 10 and 100 nM) decreased osteoclast formation in a dose-dependent manner, and, at 100 nM, significantly down-regulated the production of tumor necrosis factor-α (TNF-α) [3].
In a double-blind, placebo-controlled 6-week trial involving 74 patients, biweekly testosterone injections (200 mg as the initial dose, increased to 400 mg after 2 weeks), followed by 12 weeks of open-label maintenance treatment, were well tolerated and effective in the short-term treatment of symptoms of clinical hypogonadism in men with symptomatic human immunodeficiency virus illness, restoring libido and energy, alleviating depressed mood, and increasing muscle mass [4].
References:
[1]. Sonneveld E, Jansen H J, Riteco J A, et al. Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicological Sciences, 2005, 83(1): 136-148.
[2]. Martínez-Fresneda L, O'Brien E, López Sebastián A, et al. In vitro supplementation of testosterone or prolactin affects spermatozoa freezability in small ruminants. Domestic Animal Endocrinology, 2020, 72: 106372.
[3]. Steffens J P, Coimbra L S, Rossa C Jr, et al. Androgen receptors and experimental bone loss - an in vivo and in vitro study. Bone. 2015, 81: 683-690.
[4]. Rabkin J G, Wagner G J, Rabkin R. A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms. Archives of General Psychiatry, 2000, 57(2): 141-156.
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