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TCS JNK 5a
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCS JNK 5a图片
CAS NO:312917-14-9
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)332.42
FormulaC20H16N2OS
CAS No.312917-14-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:20 mg/mL (60.2 mM)
Water: <1 mg/mL
Ethanol:<1 mg/mL
Other info

Chemical Name: N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide

InChi Key: WQGDQGAFSDMBLA-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23)

SMILES Code: O=C(C1=CC=CC2=CC=CC=C21)NC(S3)=C(C#N)C4=C3CCCC4

Synonyms

SC202671, JNK Inhibitor-IX, TCS-JNK-5a, TCS JNK 5a, JNK Inhibitor IX, SC-202671, SC 202671,

实验参考方法
In Vitro

In vitro activity: JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues.


Kinase Assay: TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5,<5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0.

In Vivo
Animal model
Formulation & Dosage
References

Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301; Toxicol Lett. 2009 Aug 10;188(3):236-42.