| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
Animal experiment: | The rats are fasted over night with free access to water. For stereotaxic injection, rats are anaesthetized (sodium pentobarbital, 50 mg/kg, i.p.) and immobilized in a Kopf stereotaxic frame. The rats are microinjected with 1 μg Kainic acid in 2 μL of sterilized physiological saline into the right lateral ventricle, i.e., 0.2 mm caudal from the bregma, 1.2 mm right lateral and 3.8 mm ventral according to the rat brain atlas. For control, rats are injected with same amount (2 μL) of vehicle, sterilized physiological saline. Five rats in each group are used in this study[1]. |
| 产品描述 | Kainic acid is a selective agonist of kainate receptor [1]. Kainate receptor is an ionotropic receptor that responds to glutamate. Presynaptic kainate receptor modulates GABA release and is involved in inhibitory neurotransmission. Postsynaptic kainate receptor is involved in excitatory neurotransmission. In aged rats, kainic acid significantly reduced the latency to full clonic-tonic seizures and increased the amount of seizures rats. Also, kainic acid significantly increased the release of norepinephrine (NE), ASP and GLU in aged rats with clonic-tonic seizures [1]. In neonatal rats, intrahippocampal injection of kainic acid (1 μg) significantly induced pyramidal cell death [2]. In adult rats, kainic acid significantly increased the mRNA levels of neurotrophin-4/5 (NT-4/5) in the dorsal horn and in the spinal cord white matter, and increased the mRNA level of brain-derived neurotrophic factor (BDNF) in the ventral horn. While kainic acid didn’t affect neurotrophin-3 (NT-3). These results suggested that NT-4/5 and BDNF participated in the response of the spinal cord to excitotoxic stimuli induced by kainic acid [3]. References: |
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