| CAS NO: | 110683-10-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 110683-10-8 |
| 别名 | 2-(3-(4-戊基苯基)丙烯酰胺基)苯甲酸,ACA |
| 化学名 | 2-((Z)-((E)-1-hydroxy-3-(4-pentylphenyl)allylidene)amino)benzoic acid |
| Canonical SMILES | CCCCCC1=CC=C(/C([H])=C([H])/C(O)=N/C2=CC=CC=C2C(O)=O)C=C1 |
| 分子式 | C21H23NO3 |
| 分子量 | 337.41 |
| 溶解度 | ≥ 33.7mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum phospholipase A2 (PLA2) inhibitor and TRP channel blocker [1] [2]. PLA2 enzymes are a family of structurally different enzymes including at least nine subfamilies. The mammalian TRP proteins including at least 27 members and can be grouped into TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML six subfamilies [1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad-spectrum PLA2 inhibitor and TRP channel blocker [1] [2]. In HEK293 cells transfected with human TRPM2, ACA (20 ?M) completely blocked H2O2-induced Ca2+ signals and ADPR-induced whole-cell currents with IC50 value of 1.7 ?M. ACA (20 ?M) also blocked human TRPM8-induced Ca2+ signals and TRPC6-mediated currents with IC50 values of 3.9 ?M and 2.3 ?M, respectively. ACA can serve as a useful tool for studying the function of TRPM2 in native cells [2]. In isolated pig cardiac ventricular myocytes, ACA reversibly inhibited ICl(Ca) with IC50 value of 4.2 ?M in a concentration-dependent way. ACA (50 ?M) also inhibited the cAMP-activated chloride current. References: |
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