您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > (±)-Ketoprofen-d3
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
(±)-Ketoprofen-d3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-Ketoprofen-d3图片
CAS NO:159490-55-8
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
 
Cas No.159490-55-8
别名酮洛芬D3,RP-19583-d3
Canonical SMILESO=C(C1=CC=CC(C(C(O)=O)C([2H])([2H])[2H])=C1)C2=CC=CC=C2
分子式C16H11D3O3
分子量257.3
溶解度DMSO: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(±)-Ketoprofen-d3 is intended for use as an internal standard for the quantification of (±)-ketoprofen by GC- or LC-MS. (±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 μM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant.2 Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.

References
1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys. Acta. 1209(1), 130-139 (1994).
2. Zhang, J., Xu, X., Zhu, L., et al. Preparation and pre-clinical characterization of sustained release ketoprofen implants for the management of pain and inflammation in osteoarthritis. Trop. J. Pharm. Res. 17(4), 577-582 (2018).