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3-hydroxy-DL-Kynurenine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
3-hydroxy-DL-Kynurenine图片
CAS NO:484-78-6
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
3-羟基-DL-犬尿氨酸是色氨酸的代谢物，是一种潜在的内源性神经毒素，其水平升高已在几种神经退行性疾病中得到描述。
Cas No.484-78-6
别名DL-3-羟基犬尿氨酸,DL-3-Hydroxykynurenine
化学名α,2-diamino-3-hydroxy-γ-oxo-benzenebutanoic acid
Canonical SMILESOC1=CC=CC(C(CC(N)C(O)=O)=O)=C1N
分子式C10H12N2O4
分子量224.2
溶解度DMF: 0.5 mg/ml,DMSO: 1 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

3-hydroxy-DL-Kynurenine is an active metabolite of tryptophan.1,2,3 It inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%, respectively, when used at a concentration of 100 μM.1 3-hydroxy-DL-Kynurenine is active against methicillin-resistant S. aureus (MRSA), S. epidermidis, vancomycin-resistant E. faecalis (VRE), E. coli, multidrug-resistant P. aeruginosa (MDRP), and C. albicans (IC50s = 31.2, 39.2, 57.6, 24, 25.6, and 137.6 μg/ml, respectively).2 It increases intracellular NAD+ levels and extracellular lactate dehydrogenase (LDH) activity in human neurons and astrocytes in a concentration-dependent manner.3

References
1. Badawy, A.A.-B., and Morgan, C.J. Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents. Int. Congr. Ser. 1304, 344-351 (2007).
2. Narui, K., Noguchi, N., Saito, A., et al. Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway. Biol. Pharm. Bull. 32(1), 41-44 (2009).
3. Braidy, N., Grant, R., Brew, B.J., et al. Effects of kynurenine pathway metabolites on intracellular NAD+ synthesis and cell death in human primary astrocytes and neurons. Int. J. Tryptophan Res. 2, 61-69 (2009).