| CAS NO: | 83915-83-7 |
| 包装: | 50mg |
| 市场价: | 300元 |
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 441.52 |
| Cas No. | 83915-83-7 |
| Formula | C21H35N3O7 |
| Solubility | <2.69 mg/mL in H2O insoluble in; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate |
| Canonical SMILES | C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Lisinopril是血管紧张素转换酶(ACE)的长效抑制剂,IC50值为4.7 nM [1].
Lisinopril是MK 421的赖氨酸类似物.二者皆是ACE抑制剂,能够显著抑制外源性血管紧张素I的升压反应.给予Lisinopril能降低心脏舒张压和收缩压,并提高心率.Lisinopril能显著降低血浆中血管紧张素转换酶的活性.Lisinopril提高血浆肾素水平,同时降低血浆血管紧张素II和醛固酮水平.Lisinopril目前用于治疗多种疾病,包括高血压\心力衰竭\急性心肌梗死和糖尿病肾病,Lisinopril dehydrate是此药的商品化形式[2, 3].
参考文献：
[1] Arora P K, Chauhan A. ACE INHIBITORS: A COMPREHENSIVE REVIEW. International Journal of Pharmaceutical Sciences & Research, 2013, 4(2).
[2] Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL. Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. Br J Clin Pharmacol. 1981 May;11(5):461-7.
[3] Sorrenti M, Catenacci L, Cruickshank DL, Caira MR. Lisinopril dihydrate: single-crystal x-ray structure and physicochemical characterization of derived solid forms. J Pharm Sci. 2013 Oct;102(10):3596-603. B3291
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